Dual T cell receptor alpha chain T cells in autoimmunity.

Dual T cell receptor alpha chain T cells in autoimmunity

Allelic exclusion at the T cell receptor alpha locus TCR-alpha is incomplete, as demonstrated by the presence of a number of T lymphocyte clones carrying two expressed alpha chain products. Such dual alpha chain T cells have been proposed to play a role in autoimmunity, for example, because of a second TCR-alpha beta pair having bypassed negative selection by virtue of low expression. We examin...

Dual T Cell Receptor C~ Chain T Cells in Autoimmunity Materials and Methods

Allelic exclusion at the T cell receptor et locus TCR-ot is incomplete, as demonstrated by the presence of a number of T lymphocyte clones carrying two expressed ot chain products. Such dual 0t chain T cells have been proposed to play a role in autoimmunity, for example, because of a second TCR-~x[3 pair having bypassed negative selection by virtue of low expression. We examined this hypothesis...

T cell receptor genetics, autoimmunity and asthma.

Dual T cell receptor beta chain expression on human T lymphocytes

Allelic exclusion of lymphocyte antigen receptor chains has been hypothesized as a mechanism developed by the immune system to ensure efficient lymphocyte repertoire selection and tight control of lymphocyte specificity. It was effectively shown to be operative for both the immunoglobulin (Ig) and the T cell receptor (TCR) beta chain genes. Our present observations suggest that close to 1% of h...

CD8+ T cells in autoimmunity.

Mounting evidence shows that CD8(+) T cells contribute to the initiation, progression and regulation of several pathogenic autoimmune responses in which these cells were not previously thought to play a major role. CD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines capable of signaling through death receptor...